Entactin: A possible auto-antigen in the pathogenesis of non-Goodpasture anti-GBM nephritis
نویسندگان
چکیده
منابع مشابه
Molecular architecture of the Goodpasture autoantigen in anti-GBM nephritis.
BACKGROUND In Goodpasture's disease, circulating autoantibodies bind to the noncollagenous-1 (NC1) domain of type IV collagen in the glomerular basement membrane (GBM). The specificity and molecular architecture of epitopes of tissue-bound autoantibodies are unknown. Alport's post-transplantation nephritis, which is mediated by alloantibodies against the GBM, occurs after kidney transplantation...
متن کاملAnti-GBM antibodies in Goodpasture syndrome; anatomy of an epitope.
like group (comprising a-2(IV ) itself, a-4(IV ), and Introduction a-6(IV )). Basement membranes are thin sheet-like extracellular The six a(IV ) chains di er considerably from each structures that form an anatomical barrier wherever other in their tissue distribution. The a-1( IV ) and cells meet connective tissue. They provide a substrate a-2(IV ) chains are found in all basement membranes, f...
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The suppressive effect of cyclosporin A (CyA) on the development of glomerulonephritis was evaluated in rats with either original- or crescentic-type anti-glomerular basement membrane (GBM) nephritis. CyA (2.5, 10 or 20 mg/kg) was given p.o. daily to original-type anti-GBM nephritic rats for 10 days from the day after the injection of anti-GBM serum. The development of the nephritis was dose-de...
متن کاملA possible association of partial lipodystrophy with anti-GBM nephritis (Goodpasture's syndrome).
Partial lipodystrophy is known to be associated with mesangiocapillary glomerulonephritis. A case is described of a possible association of partial lipodystrophy with anti-GBM nephritis (Goodpasture's syndrome).
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ژورنال
عنوان ژورنال: Kidney International
سال: 1990
ISSN: 0085-2538
DOI: 10.1038/ki.1990.195